Saxenda (Liraglutide)

Saxenda is a weight loss drug containing the active ingredient liraglutide. It’s taken as a daily injection and works by binding to GLP-1 receptors in the body to stimulate insulin release and suppress appetite. Saxenda helps people feel full longer and supports weight loss goals by reduced caloric intake.

Liraglutide is in a class of drugs known as GLP-1 receptor agonists. While other GLP-1s are approved as anti-diabetes medications, Saxenda is only FDA-approved for chronic weight management.

Patients using a 3 mg dose of liraglutide experience weight loss, but daily Saxenda injections make medication compliance difficult for some patients. This led to the development of other GLP-1 agonist drugs, like Wegovy and Ozempic.

While semaglutide, known as Wegovy or Ozempic, is the most prescribed medication in both the anti-diabetes and anti-obesity medication categories, Truveta Research says Saxenda is the second most prescribed anti-obesity medication.

The FDA approved Saxenda as a weight management medication for adults and adolescents aged 12 through 17. It should be used along with a low-calorie diet and increased physical activity to achieve lasting weight loss.

Doctors can prescribe Saxenda for obesity and it may also help stabilize blood sugar levels in patients with Type 2 diabetes, even though it is not FDA-approved as a diabetes treatment.

Effectiveness of Saxenda for Weight Loss

Patients have experienced significant weight loss while using Saxenda. The average weight loss in trials was 6.4% over 68 weeks, compared to less than 2% with a placebo. Participants also received counseling on diet and exercise strategies.

Saxenda effectively manages weight by suppressing appetite, slowing gastric emptying and promoting insulin production.

Saxenda and Wegovy are the only GLP-1 type medications FDA-approved for weight loss. Zepbound (tirzepatide) is a dual GLP-1/glucose insulinotropic polypeptide (GIP) agonist approved for weight loss. Other GLP-1s approved for Type 2 diabetes may also produce weight loss, but they do not have FDA approval for that use. Using a medication off-label can pose serious health risks.

Saxenda is taken in a gradually increasing dose to allow the body to adjust. The standard maintenance dose is 3.0 mg per day.

The treatment begins with a daily injection of 0.6 mg and gradually increases until the maintenance dose of 3 mg daily is reached. Some patients who do not tolerate higher doses may stay on the 1.2 mg, 1.8 mg, or 2.4 mg dose. You should return to your doctor for monitoring while you take Saxenda.

Saxenda is a pre-filled pen that delivers a maximum 3 mg dose, meant to be injected daily under the skin of your abdomen, thigh or upper arm. Rotate the injection site daily to avoid lumps. Never inject into a vein or muscle.

According to Novo Nordisk, Saxenda has a list price of $1,349 without insurance. However, the out-of-pocket price may be substantially lower if your health insurance covers it.

Consult your health care professional, pharmacy or insurance provider for updated and accurate pricing information.

Novo Nordisk previously offered a savings program for Saxenda, but it expired in 2023. Other savings programs may be available.

Saxenda has an FDA boxed warning — the Agency’s most serious warning — due to an increased risk of thyroid tumors from liraglutide. Rats and mice have developed thyroid C-cell tumors while taking liraglutide in lab tests, but it’s unclear if humans are at risk.

Who Should Not Take Saxenda?

You should not take Saxenda if you have a personal or family history of certain types of thyroid cancers. If you have the rare genetic disorder multiple endocrine neoplasia type 2 (MEN2), you should not take Saxenda. If you are pregnant or have a known allergic reaction or hypersensitivity to ingredients in Saxenda, you shouldn’t take it.

Saxenda can lead to complications in patients with medical conditions, like pancreatitis, renal disease and Type 2 diabetes requiring insulin treatment. You should discuss the risks with your health care provider before taking Saxenda.

Saxenda can cause mild gastrointestinal side effects that typically last for a few days. More severe Saxenda side effects can persist for weeks, and there are increased risks of potentially life-threatening conditions. Discuss the dangers of liraglutide with your healthcare provider before taking Saxenda.

Some patients report serious side effects while taking Saxenda. Patients taking other GLP-1 agonists, including Victoza, Ozempic and Rybelsus, may experience similar symptoms.

Patients have taken legal action against Mounjaro, a GLP-1/GIP dual agonist, claiming Eli Lilly failed to disclose the risks of severe vomiting lasting for weeks. People have also filed Ozempic lawsuits due to its serious side effects causing long-term harm to patients.

Saxenda Warnings and Precautions

Saxenda packaging warns of life-threatening complications. Those at risk should consult a health care provider before taking it.

The FDA lists Saxenda as “currently in shortage”. According to the World Health Organization, there has been a global shortage of GLP-1 medicines due to the high demand for weight loss medications. WHO warns of a 101% increase in drug shortages overall since September 2021, putting people at risk of fake or substandard drugs.

Novo Nordisk has promised increased production of its GLP-1 drugs, but some regulatory authorities predict shortages may persist until the end of 2024.